Publikationen

P.R.I.T.® Technologien wurden bereits erfolgreich eingesetzt, um die verschiedensten Fragestellungen zu bearbeiten. Über Projekte, die nicht vertraulich durchgeführt wurden, dürfen wir Ihnen in verschiedenen Referenzen berichten.

Die Untersuchung luftgetragener Schadstoffe mit allen zur Verfügung stehenden Methoden im Bereich der in vitro, ex-vivo, in vivo und human Untersuchungen bildet seit Gründung des Institutes im Jahr 1981 den Mittelpunkt der Tätigkeiten des Fraunhofer ITEM.

Die patentierten P.R.I.T.® -Technologien als eine der neuesten kontinuierlichen Entwicklungsprojekte des Hauses wurden bereits in verschiedenen Untersuchungen und Studien eingesetzt, zu denen Sie im Folgenden Referenzen finden.

EUROTOX 2017 53rd Congress of the European Societies of Toxicology, Bratislava (Slovakia), "Effect of (Co‐) exposures of Printex90 and formaldehyde on a cell‐based assay system under air‐lifted Interphase (ALI) conditions", J. Knebel1, D. Ritter1, K.Schwarz1, T.Hansen1
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover

 

10th World Congress on Alternatives and Animals in the Life Sciences (WC10), Seattle (USA), "Cigarette smoke induces biomarkers of COPD in fresh human lung tissue", H. Obernolte1, D. Ritter1, J. Knebel1, P. Braubach2, D. Jonigk2, G. Warnecke2, P. Zardo2, H.-G. Fieguth3, O. Pfennig3, A. Braun1, K. Sewald1
1Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover
2Medizinischen Hochschule Hannover
1,2Mitglied am deutschen Zentrum für Lungenforschung (DZL), Biomedical Research in Endstage and Obstructive Lung Disease (BREATH) Forschungsnetzwerk, Mitglied im Exzellenzcluster Regenerative Biology to Reconstructive Therapy (REBIRTH), Hannover
3KRH Kliniken, Germany

 

ECOPA SSCT Workshop 2017, Helsinki (Finland), "Improvements for testing of airborne materials using a cell-based in vitro approach for a more reliable data collection ", J. Knebel1, D. Ritter1, T. Hansen1, C. Brodbeck2
1Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover
2Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI, Sankt Augustin

 

Nanocluster Meeting 2017 Karlsruhe (Germany), " Effekt von Carbon Black Nanopartikeln (CBNP) auf gesunde und vorgeschädigte Lungenzellen und PCLS ", O. Danov, J. Knebel, O. Creutzenberg, A. Braun, K. Sewald und T. Hansen
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover

 

Fraunhofer InnoVisions "Kubus gegen Tierversuche"

 

SOT 56th Annual Meeting and ToxExpo 2017, Baltimore (USA), "Characterization of Ci-huAEC airway epithelial cells for air-liquid exposure experiments", J. Knebel1, D. Ritter1, L.Schulz1, M.Niehof1, C. Ziemann1, T.May2, T. Hansen1
1Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover
2InSCREENex GmbH - Braunschweig - Germany

 

Models of Lung Disease Workshop 2017, Hannover (Germany), "Cigarette Smoke induced Inflammation and Cytotoxicity in viable lung tissue", H. Obernolte1, D. Ritter1, J. Knebel1, P. Braubach2, D. Jonigk2, G. Warnecke2, M. Krüger2, H.-G. Fieguth3, O. Pfennig3, A. Braun1, K. Sewald1
1Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM, Hannover
2Medizinischen Hochschule Hannover
1,2Mitglied am deutschen Zentrum für Lungenforschung (DZL), Biomedical Research in Endstage and Obstructive Lung Disease (BREATH) Forschungsnetzwerk, Mitglied im Exzellenzcluster Regenerative Biology to Reconstructive Therapy (REBIRTH), Hannover

3KRH Kliniken, Germany

 

 

EUROTOX September 2016, Sevilla, Spain, C. Brodbeck, D. Ritter, J. Knebel, "Use of Computational Fluid Dynamics for optimization of cell-based in vitro methods in inhalation research", Postersession

EMBL Microfluidics July 2016, Heidelberg, Germany, C. Brodbeck, D. Ritter, J. Knebel, "Applying CFD for the Design of an Air-Liquid Interface In-Vitro Testing Method for Inhalable Compounds", Postersession

55th Annual Meeting of the Society of Toxicology 2016, New Orleans (USA), Postersession, D. Ritter, A. Bitsch, M. Elend, S. Schuchardt, T. Hansen, C. Brodbeck, J. Knebel, A. Fuchs, C,. Gronewold, R. Fautz, "Development of an experimental cell-based approach to evaluate biological effects of aerosols from the application of hair-straightening products in vitro using relevant product application and cell exposure conditions"

Workshop "From Mice to Men: Road to Human Relevant Alternative Methods for Safety Assessment" of the BIO.NRW.academy, Henkel Düsseldorf, Postersession, C. Brodbeck, D. Ritter, J. Knebel, "Evaluation of biological effects of airborne material using an improved cell-based in vitro approach", May 2016

 

 

 

 

54th Annual Meeting of the Society of Toxicology 2015, San Diego (USA), Luncheon Seminar, A. Braun, D. Ritter, K. Sewald, D. Walter, A. Bitsch, "Alternative Methods in inhalation toxicology"

54th Annual Meeting of the Society of Toxicology 2015, San Diego (USA), Postersession, D. Ritter, E. Krakor, J. Knebel "Acute inhalation toxicity of volatile organic compounds - application of an improved cell-based in vitro procedure"

NAFEMS World Congress 2015, San Diego (USA), Präsentation und Paper "Improvements of an Air-Liquid Interface In-Vitro Testing Method for Inhalable Compounds using CFD-Methods", D.Ritter, J. Knebel, C. Brodbeck [abstract]

Advances in Toxicology 2014, Ritter, D., Knebel, J, "Investigations of the biological effects of airborne and inhalable substances by cell-based in vitro methods: fundamental improvements to the ALI concept", Advances in Toxicology Volume 2014, Article ID 185201, 11 pages

Advances in Aerosol Dosimetry Research 2014, Irvine (USA), Präsentation, D. Ritter, J. Knebel. "Current developments in the field of testing inhalable compounds in vitro based on the air-lifted-interface (ALI) technique"

8th International Symposium on Modern Principles of air Monitoring and Biomonitoring, Airmon 2014, Marseille (Frankreich), Postersession, D. Ritter, C. Brodbeck, J.Knebel "Biological monitoring of inhalable substances in vitro - development of an improved test method based on the air-liquid-interface (ALI) cell culture technique"

9th World Congress on Alternatives and Animal Use in the Life Sciences 2014, Prag (Tschechien), Postersession "Fundamental improvements of the Air-Liquid Interface technique for use in in-vitro inhalation toxciology", J. Knebel, D.Ritter, C. Brodbeck

Annual Conference 2013 of the Association of inhalation toxicologists, Hannover (Deutschland), Präsentation, D. Ritter "In vitro human cell culture systems and air liquid interface techniques"

European Aerosol Conference 2013, Prag (Tschechien), Postersession "Influence of the Geometry of an Aerosol Conducting System on the Deposition of Particles from Inhalable Aerosols on Cellular Surfaces In-Vitro"

Scandinavian Society for Cell Toxicology (SSCT) Workshop 2013, Charlottenlund (Dänemark), Postersession "Biological effects of inhalable compounds – improvements of the in vitro testing method", D.Ritter, J. Knebel, C. Brodbeck, Pasi Jalava